Twenty Lonely Planet City Guides have been made available, including London, New York, Tokyo and Dubai at a price of £9.49. For a limited time, the San Francisco guide will be available for free to celebrate the launch.
The guides use the iPhone's and iPod Touch's GPS and scrolling touch-screen features, allowing access to interactive maps, which can be viewed offline and used to plot itineraries and locate sites and restaurants in the immediate vicinity.
The guides also come stocked with pictures from Lonely Planet's photography team.
Lonely Planet's Audio Phrasebooks were some of the first travel products available in the App Store and have generated over 300,000 downloads since their launch.
Chris Boden, head of wireless and innovation at Lonely Planet, said the interactive guide books were the next obvious step for the company.
Boden said: "We've tried to take advantage of the iPhone's location awareness, vast data storage and simple user interface to re-imagine our city guidebook series to help travellers get to the heart of some of the world's most exciting cities from the convenience of their hip pocket."
Other iPhone city guides include Melbourne, Dublin, Barcelona, Rome, Paris, Prague, Amsterdam, Bangkok, Madrid, Miami, Seoul, Berlin, Cape Town, Singapore and Mexico City.
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