The event, which is usually held in Germany every two years, will showcase the 20 Paralympic sports, giving the public a chance to learn more and meet the athletes.
It will take place on 8 September, the day before tickets for the Paralympic Games go on sale.
The last International Paralympic Day was held in Berlin in front of the Brandenburg Gate.
"London 2012 for us is about more than just chasing down every medal that we can. It’s about putting Paralympic sport on firmly on the map so that the nation sees and appreciates our brilliant sportsmen and women," said chair of the British Paralympic Association Tim Reddish OBE.
"International Paralympic Day is a great way of helping that engagement process and we’re thrilled to be involved," he added.
An announcement on Paralympic Games ticket prices and the sports competition schedule will be made in May.
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