The deal involves headline sponsorship for the event, which is now in its 13th year and is set to take place in London on September 24.
The sponsorship package also includes a joint awards logo, retail activity and branding both at the ceremony as well as within the magazine. In addition, Littlewoods Direct will sponsor individual awards for Best Soap, Best Dressed Soap Star and Sexiest Female Soap Star.
Mat Court, Inside Soap advertising director, said: "The fact that Littlewoods Direct are our main partner for the awards for the third year running is a testament to how a partnership really can, and should, work."
Hachette Filipacchi UK-owned Inside Soap has a circulation 189,183 copies a week, according to latest ABC figures for July to December last year.