Madden will oversee all on-air and off-air marketing strategies for the channel and work with other divisions of The Walt Disney Company.
Prior to her time at Thinkbox, Madden was head of marketing at BBC One. Madden will report to Michael Cairns, general manager for Disney Channels UK and Ireland.
Cairns said: "Christine Madden joins us with a wealth of marketing experience from some of the UK's leading broadcasters. She will be instrumental in helping to continue to build the Disney Channel brand in UK and Ireland."
Madden said: "This is a great opportunity to work on a global entertainment brand that continually delivers successful television shows worldwide.
"I look forward to focusing on developing innovative and exciting marketing campaigns that resonate with kids and parents across the UK."