The agency has been tasked with producing a multimedia campaign to run across countries including the UK, the US, France, Germany, Japan and Australia.
The work will focus on the release of tracks from John Lennon's solo career, which are being re-recorded by contemporary artists for a charity fundraising drive.
Marketing activity will kick off later this year. It is being designed to appeal to a younger audience than Amnesty traditionally targets and will therefore adopt an emphasis on new media.
The tracks will be released as singles, music videos and a compilation album. The music will be available online and as mobile phone downloads.
Lennon's wife Yoko Ono donated the recording rights to 'Imagine' and the rest of his songs in 2002.
Stephanie Newman, Amnesty International senior project manager, said: "Music is itself an expression of human rights and it's an ideal vehicle for reaching out to a broad audience and getting across a message of action and social change."
She added: "Through this collection of contemporary versions of Lennon tracks recorded exclusively for Amnesty, a new generation will be able to experience and express their rights."
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