
The deal has taken nine months of negotiation between Google-owned YouTube and the PRS for music, which is the body that collects royalties on behalf of songwriters, composers and music publishers.
The deal lasts until 2012 and will be valued depending on how many times videos are viewed. It is thought YouTube has agreed to pay a lump sum up front as part of the deal.
YouTube was forced to block more than 10,000 music videos related to PRS members in March. These videos will now be reinstated on the site.
Labels covered by the deal include Universal, Sony and EMI as well as some independent labels.
PRS is currently trying to negotiate a similar deal with social networking site Myspace.