Thomas Cook will provide details on package deals, flights, hotels and car rental through the Tiscali Travel , offering special promotions to registered Tiscali customers.
In addition, the website will feature editorial content on holidays, and a targeted opt-in email campaign offering visitors holiday deals throughout the year.
Tiscali said creating a comprehensive travel website came in response to a survey that found 55% of its customers took more than one holiday a year.
Alex Hole, online media director at Tiscali UK, said: "Travel is one of the most popular channels on Tiscali.co.uk and Thomas Cook ticked all the boxes providing both a wide range of unbeatable offers to our visitors and unparalleled customer service."
Thomas Cook was selected as Tiscali's travel partner following a strategic review involving six other rival travel businesses.