Vauxhall's sponsorship includes 'Matchday Live' on air on Saturday from 12-5pm and the 'Friday Premiership Show', on air from 7-10pm.
The deal was brokered between Vauxhall, its media agency Carat and TalkSport's sponsorship team. It is believed to be worth a seven-figure sum per year.
Matt Wilson, director of sponsorship and promotion at TalkSport, said: "For the first time, people will be able to hear a very different style of top flight English football commentary from the traditional sound of the BBC that they have been listening to for 80 years.
"Vauxhall Commercial Vehicles has been a strong supporter of the station since it launched and we are delighted to have them as sponsors of our live Saturday afternoon football coverage."