The office will initially focus on business development and client services and will help the agency find work from mainland clients.
Jonathan Cummings, managing director of Start Creative Hong Kong, said: "Since opening in Hong Kong, it has been clear that there are many opportunities for us in mainland China and to explore these further we need to have a presence on the ground."
To head the new office Start Creative has hired Tori Liu, who previously worked for Creative Connexions, a consultancy specialising in promoting UK creativity in China.
The agency has already worked on a project in China, having designed a flagship Adidas store which opened last year in Beijing, working with its partner agency, environments specialist JudgeGill.
Start Creative is headquartered in the UK and also has offices in Dubai and Mumbai.