The Festival of the World programme will run from 1 June-9 September 2012 (the last day of the Paralympic Games) and will form part of the London 2012 Festival.
Artistes include singers Bryn Terfel and Baaba Maal, Gustavo Dudamel and the Simón Bolívar Symphony, and Dancing Voices, a performance by 150 dancers and 50 singers over the age of 60.
Other highlights include A Room for London, a one-bedroom installation in the form of a riverboat, situated on the roof of the Queen Elizabeth Hall.
The event will also feature the largest poetry festival ever staged in the UK, Poetry Parnassus, which will see poets from each of the 204 competing Olympic nations come together for a week-long celebratory gathering.
The event was inspired by Baron Pierre de Coubertin, the founder of the modern Olympic movement.
Jude Kelly, artistic director of Southbank Centre, said: "Pierre de Coubertin’s vision of a better world through education, culture and sport for all is as relevant today as it was at the end of the 19th century. Festival of the World will be a space for artists and visitors from around the world to enjoy a three-month celebration of the arts and its power to transform lives."
The Southbank Centre will also play a part in the two-day BT River of Music festival . It will host the Africa Stage adjacent to Jubilee Gardens, one of six stages showcasing music from each continent along the Thames.
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