The 23-year-old's removal from the house comes less than two weeks after Channel 4 had to remove Alex from the house for issuing threats to her housemates from her "gangster friends".
Flamboyant dancer Dennis spat in the face of Somalian Muslim housemate Mohamed during an argument at 12.45am this morning, which resulted from a prank played by Rex that ended in a picture painted by Jennifer being slightly defaced.
The voice of Big Brother intervened immediately to break up the argument and the "as live" streaming from the house on E4 was cut.
All the housemates involved in the argument were sent to separate bedrooms and kept apart for the rest of the night.
Dennis and Mohamed were called separately to the diary room in the early hours to discuss the incident.
After production staff and executives at Channel 4 reviewed the footage this morning, Dennis was called to the diary room a second time at 1.15pm and told he was immediately being removed from the house.
Following his removal, Big Brother continued to call a number of housemates to the diary room to discuss their involvement in the argument and remind them of the rules governing housemates' behaviour.
A spokesperson for Channel 4 said: "Spitting in someone's face is seriously offensive and Mohamed was understandably upset.
"Big Brother has very clear rules about offensive behaviour. Like all housemates Dennis, was clearly informed before entering the house that he faced eviction if he acted in an unacceptable manner."
Last year, Emily Parr was removed from the house for using a racially offensive word to a black housemate.
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