The campaign, created by Mother, shows celebrity lookalikes of unlikely couples entering into the seasonal spirit of goodwill and putting aside their differences in order to share a festive drink.
The pairs include Gordon Brown and Tony Blair, Jose Mourinho and Roman Abramovich, and Pete Doherty and Kate Moss.
The pictures use the caption "Sch...you know who should mix this Christmas".
The work breaks on December 3 and will appear on billboards in London for a limited period.
Alison Jackson previously created work for Schweppes from 2001 to 2003, which won her a number of creative awards.
She became famous in 1999 with her lookalike photographs of celebrities in compromising situations, including pictures that apparently showed Princess Diana and Dodi Al-Fayed with a mixed-race love child. She went on to win a Bafta for the BBC Two series 'Doubletake'.