Scholz & Friends Bucharest will be established as an independent agency operating within Lowe Group in a joint venture company.
It will be operational from September this year and will offer clients "enlarged and excellent" services drawing on Lowe's expertise.
The alliance with Lowe brings to an end Scholz's previous relationship with GAV Balkanski.
Lowe & Partners Romania has been represented in Eastern Europe for 15 years working for clients including Unilever, Coca-Cola, Electrolux and Johnson & Johnson.
Scholz & Friends is the only European agency network to be managed from Germany and works for clients including Tchibo, Mercedes-Benz and Siemens. Along with its headquarters in Berlin and Hamburg, the Scholz & Friends network has over 20 subsidiaries throughout Europe.
Veronica Savanciuc, president and CEO of Lowe Romania, said: "Lowe & Partners and Scholz & Friends both are committed to provide creative business solutions and comprehensive services for our clients.
"We look forward to working together and are happy to support our strategic alliance partner in Romania."