Salt and added sugar will be reduced by 25%, while saturated fat will be reduced by 15%, the company says.
It will also increase the amount of whole grains, fruits and vegetables, nuts, seeds and low-fat dairy in its product portfolio.
A UK spokeswoman for the company said the UK had already made substantial progress, for example reducing salt in its crisps and snacks by between 25% and 55% since 2006.
The pledge follows similar moves by other US food companies in the face of pressure from their home government. Kraft, Campbell and ConAgra have all said they will make reductions.
Indra Nooyi, chairman and chief executive of PepsiCo, said: "We believe that a healthier future for all people and our planet means a healthier future for PepsiCo.
"These commitments are shared by all of our businesses and reflect our focus on profitable, long-term growth, and will guide us as we continue to build a portfolio of enjoyable and wholesome foods and beverages for consumers around the world."
Last week, PepsiCo said it would stop selling full sugar soft drinks in primary and secondary schools by 2012.
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