It is the first venture across the Atlantic for the France Telecom-owned Orange Advertising Network business, which has so far concentrated on Europe.
It is offering advertisers access to an audience of 21m unique monthly users in the US and Latin America on more than 20 Hispanic publisher sites it has signed up.
These sites include Orange Spain's own StarMedia.com portal, which has local operations in Latin America and the US, the website for Spanish newspaper El Mundo, and Spil Games.
Luc Tran Thang, vice-president advertising at Orange, said: "Both the US Hispanic and Latin American markets represent tremendous potential in terms of online advertising growth."
The move expands the sales house's overall reach to 343m unique users in 60 countries and comes three months after .