News Corp said its Wapping site would be redeveloped and is expected to be ready to house its various media business by 2012. BSkyB, its Isleworth-based satellite TV subsidiary, is not included in the move.
The decision reverses an earlier plan to move the News International offices, which have occupied the site since 1986, from Wapping to central London.
News Corp shelved the plan in August and it has now revealed it has picked architectural practice Future Systems to transform the site into a "campus", making use of the space vacated by the printing presses that were decommissioned earlier this year after production moved to News International's new print site at Broxbourne.
It said it would work closely with Tower Hamlets Borough Council on the redevelopment, which will take place alongside the regeneration of the area for the 2012 Olympics.
James Murdoch, chairman and chief executive of Europe and Asia at News Corp, said: "Throughout our history, News Corporation has challenged conventions and we hope this building will provide benefits to the business that can't be found in traditional commercial real estate.
"Wapping is not only important as a physical site, but also it is a symbol of how bold individuals, working together, can advance the world of media and thereby contribute to life in Britain.
"We have chosen to create an exciting campus that is flexible, environmentally sustainable and where colleagues can do the best work of their lives."
Rupert Murdoch's decision to move News International to Wapping in 1986 was met with violent strikes by the printworkers' union.
For Harper Collins the move to East London will see it move across town. The publisher is currently located in Hammersmith, Fox is in Soho, MySpace is on New Oxford Street and Dow Jones is based across the City of London and central London.
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