Lined up to present is Gary King, a former Virgin Radio, Heart London and Capital Radio DJ, who is currently a morning host on Emap digital station Mojo.
The show will follow Iain Lee's drivetime 4-7pm slot, and is part of a revamp that includes the signing of agony aunt Anna Raeburn from January 3 and recent arrival Andy Crane as a Sunday morning presenter.
Contestants will attempt to answer as many trivia questions as possible in a minute, and have the option of gambling their final score in order to gain the chance to win more points.
The player with the most points each month will get the chance to play for the £100,000 prize.
David Lloyd, managing director of LBC, said: "The quiz concept is another bold move for a rejuvenated LBC 97.3FM, offering a real opportunity to bring in a new and fresher audience, and offering a powerful sponsorship opportunity."
The station's share of listening in London has grown over the past year from 2.2% to 2.9%.
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