Drayton joins from Phorm, the controversial behavioural ad targeting company, where he was chief executive for the past two years.
He left just weeks after four board members departed the company amid differences over strategy. Phorm has been criticised over fears that its technology will allow internet companies to spy on users.
InSkin already has commercial partnerships with Telegraph Media Group, Tiscali and Dennis Publishing.
Users of video content on these publishers' sites are able to pause the video and click on the wrap-around "skin" to view an interactive ad that rolls up and overlays the player.
InSkin has also signed an agreement with video ad outfit Utarget to partner its sales team in reaching brand advertisers.
Drayton said: "InSkin is an irresistible opportunity for me. It combines the explosion in online video consumption, the ability to drive significant new revenues for publishers, and a dynamic new, tailored opportunity for creative agencies and advertising clients."
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