The Victoria Secret's model appears in the global ad backing the release of Activision's 'Guitar Hero World Tour', which hits the UK on November 7.
In the ad, Klum is shown lip-syncing to Bob Seger's 'Old Time Rock and Roll', while dancing around the living room with the wireless guitar controller, after stripping to her underwear at the start of the commercial.
The German-born model is one of the world's most famous supermodels, having branched out beyond the catwalk to TV presenting in programmes such as 'Project Runway' and 'Germany's Next Top Model'.
Last month, Klum donned a milkmaid's outfit as the latest star to appear in the long-running US-only "Got Milk?" ad campaign.
'Risky Business' is the movie credited with turning Cruise into a movie star. He stars as the teenage son of wealthy suburban parents who cuts loose while they leave him on his own to go on holiday.