The title has been redesigned to give it a more contemporary image and will have a new logo. It goes on sale from September 2.
The relaunch will be a test of the loyalty of Inside Soap's readers to see if the same number who buy the title every other week will buy it each week.
The magazine has a circulation of 247,699 every two weeks, compared with Soaplife's 115,071 and Hachette stablemate All About Soap's 106,049 every week.
Hachette believes the new-look magazine, which has been developed following months of research and will contain more gossip, storylines and secrets of the stars from all the soaps and popular TV dramas, will drive readers to buy it more regularly.
Inside Soap was launched 11 years ago as a monthly by Attic Futura, which was bought by Hachette for £40m last year. The magazine went fortnightly in March 1996 and doubled its circulation in the next two years.
Kevin Hand, chairman of Hachette Filipacchi UK, said the magazine was part of the publisher's long-term goal to expand through launches.
He said: "Inside Soap has long been the choice of the majority of discerning soap viewers and the demand for us to take it weekly has been enormous. Now Hachette Filipacchi is firmly established in the UK, we are uniquely well placed for this sort of initiative as we actively seek opportunities to expand through launches and through generic growth in the different sectors of the market."
Last month, the publisher increased the frequency of ElleGirl to bi-monthly from quarterly, and there are also plans afoot to develop its other titles such as Red, Sugar and B.
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