The picture-led provides new and archived Daily Mail and The Mail on Sunday articles, travel features, destination guides, weekly travel blogs, breaking news and consumer stories.
Users can share their travel experiences by posting their own videos, photos and stories online.
The site will also provide a booking service for holidays, flights, hotels, car hire and the Eurostar.
Andrew Say, classified advertising director of the Daily Mail, said: "The readers of the Daily Mail and The Mail on Sunday take more holidays and spend more on holidays, both in the UK and abroad, than the readers of any other national newspapers.
"This is why our titles are the essential element of successful schedules and why greater access to this hugely responsive audience through TravelMail will be of such importance to travel advertisers."
Last week, the Daily Mail suffered the largest drop in monthly circulation figures among the national daily newspaper market, suffering a 1.81% decrease in April to 2,300,420 copies, according to the latest ABC figures. Its six-month average is down 2.15% to 2,323,858 copies.