This time, more than 250 stations are involved and the organisers have split programming across five main station groups, banded together by their normal music output such as adult contemporary or rock.
The event has not been intended to be sold as a sponsorship opportunity, according to a spokeswoman for the commercial radio trade body RadioCentre. The initiative will be broadcast across three specific radio network hubs.
The pop network will reach 15m people, include stations such as London's Capital Radio, and feature daily lunchtime sessions and exclusive artist interviews with Amy Winehouse, Paolo Nutini and Mika.
The adult contemporary network will reach 7.5m, include networks such as Heart and Real Radio, and will run a listener-voted best UK artist chart together with daily sessions including James Blunt.
There is also a listener vote for greatest UK guitar band on the rock network, which will consist of Virgin Radio, Kerrang!, Xfm and Planet Rock, reaching 5.2m.
Chrysalis' Galaxy and Emap's Kiss will come together to form the urban network, reaching 5.4m listeners, and offering performances from Jamiroquai and Jamelia. The two brands recently embarked on a partnership to share a degree of programming.
Finally, the gold network will run a series of documentaries about the stories behind individual songs. The network includes Emap's Magic and GCap's Capital Gold and reaches 3m.
Andrew Harrison, chief executive of RadioCentre, said: "The great thing about commercial radio is that it offers an incredible breadth of output for listeners right across the board."
Emap TV will also be supporting the event throughout the course of the week via programming on Q and The Hits.