The three-month partnership with the RSPCA goes live on 15 September and will centre on a selection of photographs and stories about dogs seeking a new home.
Users can click on the image of the dog they like best to sponsor it and will have the option of selecting the image for their homepage. Ask Jeeves will also donate 50p for every user who does so.
Jeeves, the search engine's butler character, will appear on the homepage, holding a dog and posing his daily question, which will be about dogs. The site will be promoted on the Ask Jeeves' Facebook and Twitter pages.
Ask Jeeves will also launch a campaign for Breakthrough Breast Cancer on 4 October to support breast cancer awareness month and will donate 50p for every user who sets a pink theme on their homepage. The butler Jeeves will be wearing a pink tie for the month, rather than the characteristic red one.
Sarah Bartlett, Ask Jeeves marketing director, said the question and answer site receives vast numbers of questions relating to animals and breast cancer so it wanted to support campaigns that appeal to its users.
Ask Jeeves is planning to roll out a social platform by the end of the year. It will combine its question answering search capabilities with a community built to answer users' questions and has already launched a version in the US.
To celebrate its 10th anniversary, Ask Jeeves will be setting up a microsite on which it will invite users to answer some of the questions it has been asked over the past decade
Ask Jeeves was first launched in 1997, specialising in answering specific questions from the users using a cartoon butler Jeeves. It changed its name to Ask.com in 2006, dropping the butler character, but brought it back when .
The search engine claims to have 18 million users in the UK.