The financial services brand made the appointments following a three-month pitch process that involved a number of roster and non-roster agencies.
R/GA will be responsible for handling the digital advertising in markets including the US and Latin America, with MRM Worldwide working on campaigns that will be implemented across Europe.
Before the review, MasterCard worked with a number of digital agencies on a country-by-country basis, including MRM Worldwide, Mercer Bell and XM.
McCann Erickson, which handles MasterCard's above-the-line advertising in most markets, is unaffected by the appointment.
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