Publicis in the West will be responsible for the brand's global brand strategy and creative, while Digitas will handle online creative and media.
The agencies picked up the account following an internally conducted review involving four un-named agencies.
Mike Butler, the HomeAway chief commercial officer, said: "Digitas and Publicis in the West create a best-of-breed global agency for HomeAway.
"We are excited to expand our marketing capabilities and look forward to making HomeAway a household name in travel and the most trusted brand in the industry for vacation rental homeowners and property managers."
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