The airline's debut TV advertising in the US will air during the major league baseball playoffs.
The campaign, created by RKCR/Y&R, breaks in the UK this Sunday (3 October) on Sky at 5pm during the Arsenal v Chelsea game. Media has been handled by MGM OMD.
It features a series of surreal vignettes designed to highlight the experiences of flying with the private airline, accompanied by 'Feeling Good' by Muse on the soundtrack.
The campaign also includes Virgin Atlantic's first cinemas activity since 2006 and carries the strapline "You're airline's either got it or it hasn't".
It follows Virgin's 2009 "Still red hot" 25th birthday campaign.
Paul Dickinson, director of sales and marketing for Virgin Atlantic, said: "Our objective in producing this TV ad was to bring to life the 'it' that makes Virgin Atlantic such a special and unique airline."