The Super Bowl, which takes place in February, is the NFL's flagship event and is being shown on terrestrial TV for the second year running.
The tie-up, brokered by Mediator, will run in January on Freeserve's rewards portal. Members can participate in an interactive NFL game giving them the chance to win weekly prizes.
"This is an important element of our campaign to rejuvenate the public's interest in NFL," said NFL Europe vice-president of planning and development Alistair Kirkwood.