The department will now be called Telegraph Media Solutions and will consist of nine hubs, each containing about 15 people.
Executive director Dave King said the move was in response to client, demand, adding: "The point here is that the customer is king. We are doing this in response to client demand and because our team is capable of doing it."
Agencies welcomed the change. Dominic Williams, Carat's head of press, said: "Under the new structure there is more focus on agencies and clients, which means they can spend more time and energy on solutions. "A lot of media owners talk about working in this way, but they [The Telegraph] are actually doing it."
There are four agency hubs, headed by two agency sales directors - Andrew Morley, formerly business development director, and Rory Bett, sales director magazines.
There are also four hubs for the key verticals: travel, recruitment, direct and property. These deal with classified, display and online sales related to the four areas and are headed by classified sales director Alex Foster.
The final hub deals with Manchester sales and is headed by regional sales director of display, Gary Frielick, and regional sales director of classified, Michelle Turner.
Ken Breen, formerly sales director of newspapers and online is now advertising operations director with responsibility for maximising inventory across the board and ensuring the hubs deliver.
Sarah Newton, director of Telegraph Create, the creative solutions and sponsorship team, will now also be responsible for a new project to develop Telegraph-branded conferences and exhibitions.
Morley and Bett will report to group trading director Jim Freeman. Meanwhile Foster, Breen and Newton will report into group sales director Mathew Watkins.
The teams will be given a three-month training programme, but will also learn "on the job", which will "widen their career paths", according to King.