The campaign, created by TDA, will also promote the traditional ways people can sponsor cats, and existing donors will be given the opportunity to upgrade.
Supporters will be invited to open days at the National Cat Centre, where they can see the cats and talk to the staff in the hope they will become regular donors and feel part of the team.
The direct marketing activity will include a press ad and insert in The Cat magazine and a direct mail pack sent to around 70,000 warm contacts and 20,000 cold prospects.
Sarah Don-Bramah, account director at TDA, said: "We have firmly positioned the donor right at the heart of this strategy.
"We believe that the interactive approach will enable Cats Protection to build an enduring and rewarding relationship with its supporters."
Janet Wickens, head of fundraising and communications at Cats Protection, said: "Interactive Cat Cabin sponsorship is an exciting way for supporters to engage with the charity and see first hand how their donations help a multitude of cats."
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