The 94-store office supplies and stationery retailer began the ad review after acquiring rival Office World for £32.5m last August.
The process stalled when marketing director John Laidlaw left without a job to go to at Christmas. Commercial director Theo Mondij has since assumed responsibility for marketing.
Clark McKay & Walpole has pitched for the work against RPM3, Maher Bird Associates and Joshua.
Staples' decision to take on a direct agency is part of its growth strategy of targeting businesses to suit its out-of-town, warehouse-style shops.
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