AIS won the entire below-the-line business following a two-way pitch against an undisclosed agency.
AIS will work with Scope's advertising agency Citigate on tackling the discrimination and prejudice faced by disabled people in the UK through the Time To Get Equal campaign, which was devised by Citigate.
Scope said that it did not want to appoint a traditional charity direct marketing agency, but rather one that had a track record on working with challenger brands, such as AIS has done with Skoda.
Stuart Archibald, managing partner at AIS, said: "Scope is a well-established charity, looking for change, which is an excellent starting point for us as their new agency."
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