The campaign is aimed at raising awareness of the risks and harms of cocaine use among 15- to 18-year-olds.
The ads show a dog, named Pablo, on a quest to find out the truth about the drug by questioning the key players from the world of coke including the dealer, the user, a bag of cocaine, a heart, a nostril and a bank note.
The TV ad, created by Mother, first airs tonight on Channel 4, and will continue to be broadcast on Channel 4 and satellite channels in programming which targets the 15- to 18-year-old audience.
Digital advertising, produced by Profero, will run concurrently on a range of internet sites. The campaign was seeded online by viral agency Rubber Republic.
Frank spokeswoman Sarah Graham, said: "No animals were hurt in the creation of this ad -- unlike in the cocaine trade.
"Some young people may perceive cocaine to be a harmless party drug but they don't realise the destruction it causes.
"Users can suffer serious harm to their mental and physical health, while the cocaine supply chain also harms people and the environment."
Frank claims that despite an overall decrease in drug use, cocaine use has remained stable amongst 16- to 24-year-olds at 5%.
It said its helpline has seen an increase in calls about the drug from 14% of all calls in 2005 to 23% in 2008.