The exit is thought to be part of News International's major cost-cutting drive across its commercial operations, which has accounted for a number of senior personnel departures.
It is unclear whether Cassano has a job to go to.
Cassano has held the job of head of agency strategy at News International since 2008, where he was responsible for the day-to-day running of relations with Omnicom and Aegis.
He was previously head of strategy and planning for the publisher of The Times, The Sunday Times and The Sun, where he was responsible for a team of 25.
He has also held the role of communication strategist at News International.
Prior to his time at News International, Cassano spent over 10 years at Manning Gottleib OMD, where he held a number of roles. These include head of creative media, group account director, and account director.
News International was unavailable for comment.
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