A story in the Wall Street Journal reported that Newsweek's revamp will cement a move away from a news to an opinion-based title that would see it compete more closely with publications like the Economist.
The latest round of cuts follow the loss of 111 jobs earlier this year although it is not clear how many jobs will be lost this time at the title, which has a guaranteed circulation of 2.6m.
That guaranteed circulation could be cut, the WSJ says, by anything between 500,000 to one million copies. It could shed even more subs and go for a more upmarket readership, allowing it to boost advertising rates.
The Washington Post Company-owned magazine has increasingly led with hot issues rather than news and this week's cover carries the headline 'The Religious Case for Gay Marriage'.
The cover has resulted in a deluge of angry emails and religious groups leading a campaign to get readers to cancel subscriptions.
The cuts at Newsweek follow similar moves by rival publishers including Time Inc, which owns rival Time, and US News & World Report, which is reducing its frequency monthly.
Magazines
Newsweek plans staff cuts and makeover
NEW YORK - Newsweek magazine is planning to cut staff as part of a major revamp of the magazine, which is likely to result in a publication with less news, fewer subscribers and more pictures.