The financial services brand, which last launched a new TV campaign in October 2008, is to feature 'Little Britain' duo David Walliams and Matt Lucas, plus a number of England internationals, including Wayne Rooney and Frank Lampard.
England coach Fabio Capello is also set to appear in the spot by incumbent ad agency Leagas Delaney, which is due to roll out around the start of the tournament in June.
It marks a change in strategy for Nationwide, which over the past 12 months has moved away from long-term brand-building in favour of direct-response advertising.
The last TV ad, featuring the brand's "nasty banker" character played by comic Mark Benton, was the final ad in the series commissioned by former head of brand strategy Peter Gandolfi.
Since the arrival of group product and marketing director Chris Rhodes from Alliance & Leicester in April 2009, and subsequently former HSBC marketer James Boulton as divisional director for marketing, marketing activity has been restricted to direct-response press ads.
Shortly before his departure in November, Gandolfi had called a review of Nationwide's ad account, but this was cancelled and the building society retained Leagas Delaney.
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