The issue continues Time Out's close affiliation with food in London, and provides details of the best places to wine and dine or have "great meals for under a tenner".
Photographed by Eugenio Franchi, it took the team more than a day to shoot and will be printed on special glossy paper stock.
The publisher is set to show a video of the making of its site on Tuesday and will invite readers to create their own cities of food and send in the photographs, which will be posted online.
The special issue is said to have attracted strong advertising sales from London restaurants and eateries.
Graeme Tottle, commercial director of Time Out, confirmed the positive impact of the issue on ad revenues.
He said: "In these economically challenging times, restaurants recognise the opportunity to present their special offers to an audience who love to eat out, love great food but also love a bargain.
"It means more than six times more restaurants will use this issue than on average throughout the year."
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