Up to 30 guests will be able to enjoy a champagne reception and three-course lunch in three different restaurants, led by a food critic host.
The Soho odyssey will take place on 9 October, followed by the Shoreditch tour on 16 October.
The festival already offers routes around Mayfair, Piccadilly, Green Park and Park Lane.
"We are thrilled that ticket demand has been so high for the unique Gourmet Osyssey event, and it’s great that more people will now be able to enjoy these unique lunches," said festival director Simon Davis.
"We also wanted to broaden the Gourmet Odyssey geographically, so getting Shoreditch and Soho in on the action is brilliant. There are so many restaurants to celebrate in the capital and a Gourmet Odyssey is the only way to try three at one mealtime."
The London Restaurant Festival is a citywide celebration of eating out, designed to raise the profile of restaurants involved and drive footfall.
More than 800 restaurants from across the capital will each be running festival menus.
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