The trophy will be presented to Ken Keir, senior vice-president of Honda Motor Europe.
The award is presented to advertisers who distinguish themselves with "inspiring innovative marketing" and "embrace and encourage the creative work produced by their agencies".
During the last few years Honda has won numerous plaudits for the creative work produced by its agency Wieden & Kennedy London -- which have been awarded Lions across different media.
Previous wins from the car marque include the Gold Lion in 2003 for the now infamous "cog" TV ad; "grrr", which won the Film Grand Prix and a Titanium Lion in 2005; along with "choir" and the "Impossible dream" campaign, which picked up Gold in 2006.
Phil Thomas, chief executive of the Cannes Lions, said: "The essence of Cannes is all about great creative work so we are delighted to honour Honda who continue to make a tremendous effort to market their brand with imaginative, original and cutting-edge advertising."
Keir said: "Through our agencies and a great marketing team we changed our advertising direction five years ago. From that point our success has been the result of a consistent, honest approach projecting the Company's philosophy and values in an entertaining and unique style which has changed Honda awareness out of all recognition."
Elsewhere, Wieden & Kennedy Amsterdam have also scooped the Grand Prix at the Montreux, for its "First taste" campaign for soft drinks manufacturer Coca Cola.
The latest Honda TV spot from Wieden & Kennedy London breaks this week and will push Honda's recently-launched hatchback, the Civic Type R, through the engineering mantra of "Hondamentalism".
The opens with a long road. At the far end of the road we see several bright lights, and at the near end we see seven engineers. The voice of American author and comedian Garrison Keillor, familiar from previous Honda ads, comes in, saying: "An engineer once said, to build something great is like swimming in honey".
The Honda engineers set off on the long road towards the bright lights. As their journey progresses a strong wind begins to blow and becomes more intense as they continue, knocking them over and spreading debris.
They reach the lights and the Honda badge appears, a logo only carried on racing cars and Type R production vehicles. Honda explains that by working together and challenging their absolute fullest potential the scientists have reached "Hondamentalism".