Next Big Thing will run from February 5 to 14 and take place across London venues including the The Borderline, Heaven and The Jazz Cafe.
The event series is focused on up-and-coming musical talent. Mama Group, HMV's live music partner, will be involved in the organisation.
Artists including The Soft Pack, The Low Anthem and Paloma Faith will perform at the inaugural Next Big Thing.
The initiative has won praise from the music industry including chief executive of UK Music and former Undertones frontman Fergal Sharkey.
"Predicting which new artists break through has become a big deal for media and public alike in recent years, but whilst quite a bit of hype and excitement is generated in print, frustratingly for fans, they often have to wait to see these news stars in the flesh," said HMV head of live events, Jason Legg.
"We wanted to change all that by creating a highly accessible and affordable live music event to showcase the best new bands and artists, whatever their genre of music, and to introduce them to a wider audience."
The news comes after HMV aquired several live music venues, , and announced that art-house cinemas could feature in its high street stores.
As previously reported, .
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