Comics Russell Howard, Ardal O'Hanlon, Jo Brand and Rich Hall will headline the week-long event, which begins on 7 September.
More than 30 shows will take place inside a 1,000-seat tent erected in the grounds of the Old Royal Naval College, while the Greenwich Theatre will house a series of solo shows from comedy mavericks Mark Thomas, Rob Newman and Arthur Smith.
The event will also mark the 20th anniversary of South London's legendary comedy club Up The Creek.
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