New programming will include a series of five documentaries, which follow people in the grip of drug or alcohol addiction as they face-up to the threat of their loved ones abandoning them forever, under the banner 'Intervention'.
Action series 'Ocean Force' is also in the line-up following the work of US lifeguards and coast police.
Returning to the channel, which was previously known as Five Life, is the Courtney Cox series 'Dirt' and re-runs of 'Sex and the City'.
The channel will also carry the first run of 'Hidden Lives', a series of documentaries about unusual people.
The next run will be shown on Five's terrestrial channel later in the year. It will include a programme called 'Sweaty Betty', about women who have a condition that makes them perspire profusely, and 'Naked Parents'.
Hannah Barnes, director of programmes for Fiver and Five US, said: "I'm delighted to be able to announce this exciting new line up of commissions and acquisitions for Fiver. Each one is a brilliant addition to the refreshed Fiver schedule."
Five revealed the station rebrand, which is a bid to attract younger viewers to the channel, last month.