Fitzpatrick joins from Gubble.com where he was vice president of business development responsible for negotiating partnerships and distribution deals for the company.
Fitzpatrick said: "There is a huge opportunity to grow 24/7 Real Media's footprint in the UK, and I look forward to demonstrating our robust service offering for local advertisers and publishers."
Prior to Glubble.com, Fitzpatrick spent nearly five years at Lycos Europe as business development director.
Fitzpatrick's appointment follows 24/7 Real Media's recent hiring of Michael Rohowski as managing director of media for Europe, as the company continues to enlarge its global presence and enhance its service offering for European advertisers and publishers.
Jonathan Hsu, CEO of 24/7 Real Media, said: "Brian's track record confirms his aptitude as a digital media manager, making him a perfect fit to capitalise on the burgeoning UK market and grow our team there.
"Under Brian and Michael's leadership, we expect to grow our media business significantly in the UK and throughout Europe over the next few years."