The move marks The Economist's first major poster blitz in around two years.
The ads present arguments for and against each issue, which The Economist said was "created to highlight the key qualities of its editorial."
The campaign was created by Abbott Mead Vickers BBDO, with media planning and buying handled by PHD and Kinetic. It launches on the 7 June and the posters will be live until 21 June this year.
Last year, The Economist moved away from it iconic "white out of red" print work by launching a 70-second cinema ad.
The new campaign follows this shift in strategy features a black backdrop with only touches of red and white.
Yvonne Ossman, UK publisher of The Economist, said: "We believe we have a fantastic publication and have identified a significant pool of potential readers. By demonstrating to them how surprising, thought-provoking and diverse The Economist's content can be we are aiming to create a connection between our magazine and this new audience.
"By sparking engagement and debate, we believe the new poster ads do just this."
The posters are the first element of a broader communications plan that will include digital executions, an online widget and direct marketing collateral.
A sampler issue will also be available, highlighting the breadth of issues that The Economist covers.