In addition, Clark will oversee Economist.com, Intelligent Life and World In magazine, as well as being responsible for circulation marketing in Europe, Middle East and Africa.
Clark joins from Le Meridien Hotels & Resorts, where she was senior vice-president of marketing and sales from 2001 to 2004.
Previously, she worked at New York-based marketing consultancy The Phineus Company, where she specialised in product design, positioning and segmentation.
Yale-graduate Clark also spent 15 years with American Express in a range of marketing and product development roles after beginning her career with computer magazine publisher Ziff-Davis Publishing.
Clark will be based out of The Economist's London offices and travel between the US, Asia and Europe.
Andrew Rashbass, The Economist publisher, said: "She will become a key member of the senior team who will implement our aggressive growth strategy."
The Economist, which is 50% owned by Financial Times publisher Pearson, achieved a circulation of more than 1m last year.
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