The campaign is based on the theme, "You might be more of an Economist reader than you think".
Press and poster activity, which breaks on Saturday, includes seven executions in black, red and white, created by AMV BBDO, the magazine's advertising agency of record for the past 23 years.
One ad poses the question, "What's the worst thing to lose as we get older? Our teeth? Our curiosity?"
Another draws attention to the magazine's interest in global issues with the line, "The world revolves around the sun. Not the British Isles".
A third shows a butterfly net catching some but not others, alongside the copy, "You can't know everything about everything. But you can give it a good go".
Susan Clark, global marketing director of The Economist, said: "The strength of our brand, and our core brand campaign, as well as our relationship with AMV BBDO, enable us to take risks with our successful marketing to ensure we stay in tune with the marketplace.
"This constant updating and attention to relevance has fuelled our growth and keeps our image fresh and our results strong".
The posters were designed by a team of illustrators including Seymour Ghwast and Geoff McFetridge.
Cilla Snowball, chairman of AMV BBDO, said: "We want to excite curiosity and to encourage more readers to try The Economist with this work, which brings fresh momentum and modernity to our iconic campaign."
The press activity will also be supported by online ads, together with ads on coffee shop table-tops and black cab tie-up seats.