The agency will be tasked with recruiting donors to the charity as well as increasing contributions from existing supporters. The brief also covers developing support for the charity's flagship Time to Get Equal campaign. Its second Time to Get Equal week begins on 9 June.
Scope had previously worked with direct specialist Archibald Ingall Stretton, but ceased doing so more than a year ago.
In addition to direct marketing, the charity communicates with existing donors through a monthly newspaper, Disability Now.
Scope's lead agency, The Gate, which has handled strategic, brand and advertising services for the charity since 2003, is not affected by the appointment.