The campaign, which has been donated by the two companies, aims to connect with 2.5m customers in the run up to Red Nose Day.
The ads kick off on March 12 at over 2000 cash machine locations including branches of the building society itself, on high streets, in supermarkets, convenience stores, shopping malls and London Underground stations. The campaign concludes on Red Nose Day on March 16.
The onscreen creative featuring Lenny Henry and Harry Hill and highlights the Red Nose Day The creative executions complement the campaign on other media, including television, posters and online.
A reminder will also be printed on the front of every customer receipt, with approximately 600,000 customers expected to take a receipt.
Claire Pilcher, marketing officer at Comic Relief, said: "We are delighted to be working with ATM:ad for a consecutive campaign and think that their technology is a fantastic way for us to get our message out to even more people.
"The ads this year focus on driving people to watch Comic Relief - The Big One on Friday March 16. If they persuade just one more person to tune in and donate then we're happy, as every penny really does make a difference."
Jack Vincent, media sales director at ATM:ad, added: "We had great feedback from the last campaign we ran for Comic Relief 2 years ago, and we are delighted to be able to help raise awareness again this year.
"With this year's fantastic creative we are expecting the campaign to have an impact on both cash machine users and passers-by and if we can get the Comic Relief message across to even a fraction, so that they think about donating, it will be well worthwhile."
Since its launch in mid-2004, ATM:ad has carried campaigns from a wide range of sectors including travel, FMCG, internet, entertainment and government for a variety of advertisers