The show, which will air monthly at 6pm via the Channel 4 Radio from November 3, will feature live performances from New Order, Jamie T and interviews with Paul Weller, REM and John Peel's son, Tom Ravenscroft.
Channel 4 confirmed that the show would also be hosted by MTV's Emily Rose and Blur bassist Alex James from Manchester in front of a live studio audience.
It is understood that Channel 4's decision to revive 'The Tube' is part of its plans to launch a digital licence bid so it can compete with the BBC's online radio services.
James said: "This is a completely new recipe for radio; mix a whole bucket of music show with a tablespoon of contemporary art, a teaspoon of rocket science and a pinch of bottom. Stand well back and listen for an hour."
The original programme, which was produced by Tyne Tees Television for Channel 4, launched in 1982 and featured presenters Paula Yates and Jools Holland, and performances from Madonna, REM and U2.
It was forced off air for three weeks in 1987 when Holland said "groovy fucker" during a live trailer, and was axed later that year.
'The Tube''s frequent run-ins with censors hurried its demise. Show producer Malcolm Gerrie and director of programmes Andrea Wonfor eventually resigned after five series, citing "stifling bureaucracy and heavy-handed moralism".
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