The full list of guests is Sir Richard Branson, Anthony Minghella, Bono, Baroness Onora O'Neill and Ferguson.
'Today' editor Kevin Marsh said: "Last year's experiment drew such interest from well-known listeners we thought we would try it again, with a great range of new guest editors."
U2 frontman Bono, who recently reprised his role on the Band Aid single, said he was not a natural editor.
"I have to confess, I'm not a natural editor... I want to start the countdown to next year, when Britain can change the world for the poorest people on the planet."
Ferguson said she wanted to use her guest editor spot to help promote a cause close to her heart.
"'Today' is the most important news programme in Britain so I couldn't resist the chance to use it to highlight serious issues like the terribly debilitating motor neurone disease."
Baroness Onora O'Neill is a cross-bench member of the House of Lords and a writer on philosophy, ethics and justice.
Minghella has directed the new Guinness ads, as well as films including 'The English Patient' and 'The Talented Mr Ripley'.
Last year's line-up of guest editors on 'Today' included Radiohead's Thom Yorke, Professor Stephen Hawking, and former Conservative minister Lord Tebbit.
Another public figure is on the airwaves today -- Conservative Party leader Michael Howard is a guest on TalkSPORT's current affairs programme between 10am and 11am.
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