The campaign, entitled 'Tribute', will target men and women aged 70 and over and has been developed by WWAV Rapp Collins.
The campaign comprises posters, leaflets, regional press and door drops featuring the life of Bunty, who also featured in a national campaign last year alongside Charles and Hilda, who died of cancer and left a gift to Cancer Research in her will.
The regional executions of the ads describe Bunty's life and why she remembered Cancer Research in her will.
Bunty was diagnosed with breast cancer in 1982 and died in March 2005. A photograph of her looking happy and content is shown against the text: 'She knew how to live life to the full'.
The copy goes on to tell how she enjoyed singing in a choir as a girl and went on to marry and have two children. It also explains how her life was improved with the knowledge and support of Cancer Research.
Press ads will run in regional newspapers such as the Birmingham Evening Mail, the Leicester Mercury and the Yorkshire Evening Press. Over 300,000 door drops will be made and leaflets will be distributed in Cancer Research shops and community venues.
Paul Farthing, director of legacy fundraising for Cancer Research UK, said: "Highlighting information about the work done in regional areas puts people in direct contact with the work that we do, and draws a line of connection between their legacy, the scientist at work in the local lab and saving lives within their community.
"This campaign will also support the work of our community fundraisers, who play a crucial role in getting our messages to our local supporters."
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